LG Household & Health Care announced on the 30th that it has developed a new solution to alleviate female-pattern hair loss without relying on steroid-derived ingredients.

This innovation is perceived as a significant advancement, particularly in light of the limitations surrounding traditional steroid-based treatments.During the recent World Congress for Hair Research (WCHR) held in Seoul, the company presented its findings on hair loss management specifically tailored for women.

The challenge has long been identifying effective treatment options, as male hormone inhibitors and estrogen-based therapies carry significant side effects and limited applicability.In the study presented, LG Household & Health Care confirmed that a non-steroidal compound derived from Vitamin A can activate estrogen receptor alpha (ERα), a critical receptor for female hormones.

Researcher Kim Jae-yun highlighted that this substance could facilitate hair follicle activation and improve the scalp environment conducive to hair growth, marking a positive outcome in clinical evaluations related to hair thickness improvements.This research expands the scope of hair loss studies, previously focused primarily on dermal papilla cells; LG Household & Health Care proposed the possibility of targeting both dermal papilla cells and hair follicle stem cells through estrogen receptor activation.

This broadening of research focus signals a new direction in addressing female-pattern hair loss.Artificial intelligence played a pivotal role in the research process, where LG Household & Health Care simulated approximately 420,000 candidate substances to analyze binding potential and mechanism of action regarding follicle-related proteins.

By integrating lipid metabolism data and gene expression profiles associated with female-pattern hair loss, the study identified ERα as a key therapeutic target, with Vitamin A-derived compounds emerging as strong candidates for effective activation.This data-driven approach is in alignment with LG Household & Health Care's vision of being a Science-Driven Beauty & Wellness Company.

Additionally, the company revealed findings related to a newly developed ingredient, Rhamsydil. The research indicates that Rhamsydil can reduce the expression of Dickkopf-1 (DKK1), a factor that induces the dormant phase in hair follicles, thereby fostering a more favorable environment for hair growth.Rhamsydil was also identified through AI-based analytics, significantly reducing the typical exploration period from over 22 months to mere days.

LG Household & Health Care's CTO, Kang Nae-kyu, emphasized that this research exemplifies a new approach to managing female-pattern hair loss. The company plans to collaborate further with its AI research center to enhance understanding of scalp aging mechanisms and focus on developing advanced scalp and hair care solutions that promote Scalp Longevity.